The COVID-19 pandemic has had a major impact on the way people live and work. Aside from illness, the pandemic has affected employee work arrangements, social lives, and psychological states. In March 2020, many non-essential employees at the University of Iowa began working remotely. UIHC and academic units varied in their approach to remote work, with many employees continuing to work on-site, while others worked—at least part time—remotely. To capture the magnitude of its effect and to offer potential solutions, we have surveyed University of Iowa employees (faculty, staff, and postdocs) four times since May 2020 regarding their work arrangements, health, and well-being.